Extraordinary changes in the world present both risks and opportunities to health—unprecedented interconnections across borders, rapidly shifting global demographics, and changing patterns of diseases and injuries. This course will challenge your assumptions about the world’s populations, as you discover surprising similarities and unexpected differences between and within countries. Approaching the concept of health as a fundamental prerequisite for building strong societies, we will explore its connection to human rights, international relations, and sustainable development. Using case examples of contemporary health challenges, we explore the influence of social, political, and environmental determinants on health, particularly transnational risks associated with globalization. We consider solutions from an array of perspectives, contributions from within and outside the health sector, and interventions at the local, national and global levels. By the end of the course, you will be equipped to thoughtfully analyze important health challenges and appreciate how evidence is contextualized and translated to policy and action.